[{"@context":"https:\/\/schema.org\/","@type":"Article","@id":"https:\/\/www.duave.cz\/je-jako-hadi-jed-vedci-odhalili-mechanismus-umrtnosti-na-covid-19\/#Article","mainEntityOfPage":"https:\/\/www.duave.cz\/je-jako-hadi-jed-vedci-odhalili-mechanismus-umrtnosti-na-covid-19\/","headline":"Je jako had\u00ed jed! V\u011bdci odhalili mechanismus \u00famrtnosti na COVID-19","name":"Je jako had\u00ed jed! V\u011bdci odhalili mechanismus \u00famrtnosti na COVID-19","description":"Novou studii publikovali v \u010dasopise Journal of Clinical Investigation (\u010casopis pro klinick\u00e9 vy\u0161et\u0159ov\u00e1n\u00ed) v\u011bdci z University of Arizona ve spolupr\u00e1ci se Stony Brook University a Wake Forest University. Jej\u00edm v\u00fdsledkem bylo odhalen\u00ed mechanismu p\u016fsoben\u00ed nemoci COVID-19, kterou zp\u016fsobuje \u010d\u00ednsk\u00fd netop\u00fd\u0159\u00ed koronavirus SARS-CoV-2, kter\u00fd cel\u00e9 planet\u011b v uplynul\u00fdch dvou letech p\u0159ipravil po\u0159\u00e1dn\u011b pern\u00e9 chvilky. Virus ob\u011bti","datePublished":"2021-09-02","dateModified":"2023-06-14","author":{"@type":"Person","@id":"https:\/\/www.duave.cz\/author\/devene\/#Person","name":"devene","url":"https:\/\/www.duave.cz\/author\/devene\/","identifier":1,"image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/014a645f9f16d49aceddb25e316448c724bd78e7db0ee7a34c29417d5ca39ef1?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/014a645f9f16d49aceddb25e316448c724bd78e7db0ee7a34c29417d5ca39ef1?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"duave.cz","logo":{"@type":"ImageObject","@id":"\/logo.png","url":"\/logo.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.duave.cz\/wp-content\/uploads\/koronavirus%20ohro%C5%BEuje%20%C5%BEivoty.jpg","url":"https:\/\/www.duave.cz\/wp-content\/uploads\/koronavirus%20ohro%C5%BEuje%20%C5%BEivoty.jpg","height":0,"width":0},"url":"https:\/\/www.duave.cz\/je-jako-hadi-jed-vedci-odhalili-mechanismus-umrtnosti-na-covid-19\/","about":["V\u011bda"],"wordCount":439,"articleBody":"Novou studii publikovali v \u010dasopise Journal of Clinical Investigation (\u010casopis pro klinick\u00e9 vy\u0161et\u0159ov\u00e1n\u00ed) v\u011bdci z University of Arizona ve spolupr\u00e1ci se Stony Brook University a Wake Forest University. Jej\u00edm v\u00fdsledkem bylo odhalen\u00ed mechanismu p\u016fsoben\u00ed nemoci COVID-19, kterou zp\u016fsobuje \u010d\u00ednsk\u00fd netop\u00fd\u0159\u00ed koronavirus SARS-CoV-2, kter\u00fd cel\u00e9 planet\u011b v uplynul\u00fdch dvou letech p\u0159ipravil po\u0159\u00e1dn\u011b pern\u00e9 chvilky.Virus ob\u011bti otr\u00e1vilL\u00e9ka\u0159\u0161t\u00ed v\u00fdzkumn\u00edci analyzovali vzorky krve dvou kohort pacient\u016f, kte\u0159\u00ed prod\u011blali nemoc COVID-19 a p\u0159i\u0161li s velmi zaj\u00edmav\u00fdm zji\u0161t\u011bn\u00edm. Cirkulace enzymu sekretovan\u00e9 fosfolip\u00e1zy (to jsou takov\u00e9 enzymy, kter\u00e9 \u0161t\u011bp\u00ed fosfolipidy na mastn\u00e9 kyseliny a dal\u0161\u00ed slou\u010deniny) skupiny A2 m\u016f\u017ee b\u00fdt nejd\u016fle\u017eit\u011bj\u0161\u00edm faktorem p\u0159edpov\u011bdi t\u011b\u017ek\u00e9ho \u010di lehk\u00e9ho pr\u016fb\u011bhu zm\u00edn\u011bn\u00e9ho onemocn\u011bn\u00ed u infikovan\u00fdch pacient\u016f \u2013 a tak\u00e9 toho, kte\u0159\u00ed pacienti nakonec viru podlehnou.Zaj\u00edmavost\u00ed je, \u017ee zm\u00edn\u011bn\u00e9 enzymy vykazuj\u00ed velmi v\u00fdraznou podobnost s aktivn\u00edm enzymem, kter\u00fd se vyskytuje v jedu ch\u0159est\u00fd\u0161\u016f. V n\u00edzk\u00fdch koncentrac\u00edch se v\u0161ak nach\u00e1z\u00ed tak\u00e9 v t\u011blech zdrav\u00fdch jedinc\u016f a je kl\u00ed\u010dov\u00fdm \u010dinitelem p\u0159i obran\u011b t\u011bla proti bakteri\u00e1ln\u00edm infekc\u00edm, a to tak, \u017ee ni\u010d\u00ed bun\u011b\u010dn\u00e9 membr\u00e1ny mikrob\u016f.Dobr\u00fd sluha, ale zl\u00fd p\u00e1nPr\u00e1v\u011b posledn\u00ed zm\u00edn\u011bn\u00e1 vlastnost je v\u0161ak tak\u00e9 d\u016fvodem ni\u010div\u00e9ho dopadu n\u00e1kazou koronavirem na zdrav\u00ed n\u011bkter\u00fdch pacient\u016f. Zat\u00edmco v b\u011b\u017en\u00e9m imunitn\u00edm syst\u00e9mu aktivovan\u00e9 enzymy ni\u010d\u00ed membr\u00e1ny cizorod\u00fdch mikrob\u016f, v p\u0159\u00edpad\u011b infekce virem SARS-CoV-2 se obr\u00e1t\u00ed proti bu\u0148k\u00e1m t\u011bla sv\u00e9ho nositele a doslova tak rozdrt\u00ed membr\u00e1ny \u017eivotn\u011b d\u016fle\u017eit\u00fdch org\u00e1n\u016f.\u201eJe to zvonovit\u00e1 k\u0159ivka odolnosti v\u016f\u010di chorob\u00e1m versus tolerance hostitele,\u201c uvedl Floyd Chilton, hlavn\u00ed autor \u010dl\u00e1nku ve v\u011bdeck\u00e9m magaz\u00ednu. \u201eJin\u00fdmi slovy, tento enzym se sna\u017e\u00ed virus zab\u00edt, ale v ur\u010dit\u00e9m okam\u017eiku se ho uvoln\u00ed takov\u00e9 mno\u017estv\u00ed, \u017ee zni\u010d\u00ed i bun\u011b\u010dn\u00e9 membr\u00e1ny pacienta. To p\u0159isp\u00edv\u00e1 k mnoha\u010detn\u00e9mu selh\u00e1n\u00ed org\u00e1n\u016f a n\u00e1sledn\u00e9 smrti,\u201c popsal v\u011bdec.D\u00edky studii mohou l\u00e9ka\u0159i a v\u011bdci za\u010d\u00edt zkoumat inhibitory, tedy l\u00e1tky, kter\u00e9 jsou schopn\u00e9 potla\u010dit \u00fa\u010dinek zdivo\u010del\u00e9ho enzymu. Mohlo by se tak jednat o kl\u00ed\u010dov\u00e9 odhalen\u00ed na cest\u011b k z\u00e1chran\u011b \u017eivot\u016f a k ukon\u010den\u00ed sv\u011btov\u00e9 pandemie. 4.1\/5 - (8 votes) "},{"@context":"https:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Je jako had\u00ed jed! V\u011bdci odhalili mechanismus \u00famrtnosti na COVID-19","item":"https:\/\/www.duave.cz\/je-jako-hadi-jed-vedci-odhalili-mechanismus-umrtnosti-na-covid-19\/#breadcrumbitem"}]}]